Age-Related Changes in the Nasopharyngeal Microbiome Are Associated With Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection and Symptoms Among Children, Adolescents, and Young Adults비인두 미생물군집의 연령 관련 변화는 소아, 청소년 및 젊은 성인의 중증 급성 호흡기 증후군 코로나바이러스 2(SARS-CoV-2) 감염 및 증상과 관련이 있습니다Article Published on 2022-08-242022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 유전자 메커니즘, [키워드] 16S ribosomal RNA Adults age association Bacterial change Characteristics childhood children Clinical data collected coronavirus 2 Corynebacterium Course COVID-19 Defense Dolosigranulum evaluated Factor feature generalized joint attribute modeling Host host defense identify Illness severity increasingly infected individuals influence joint less magnitude mechanism Microbiome microbiome composition microbiota nasopharyngeal Nasopharyngeal swab nasopharyngeal swabs participant Pathogens pediatric pediatric microbiota. profile respiratory Respiratory pathogens respiratory symptom respiratory symptoms SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 susceptibility SARS-CoV-2-infected individual SARS-CoV-2-infected individuals Sequencing susceptibility susceptible Symptom upper respiratory [DOI] 10.1093/cid/ciac184 PMC 바로가기 [Article Type] Article
Antibodies induced by an ancestral SARS-CoV-2 strain that cross-neutralize variants from Alpha to Omicron BA.1Alpha에서 Omicron BA.1까지 변이체를 교차 중화하는 조상 SARS-CoV-2 균주에 의해 유도된 항체Article Published on 2022-08-122022-09-11 Journal: Science Immunology [Category] Fulltext, SARS, 변종, 진단, [키워드] ACE2 binding antibodies antibody B cell binding binding site breadth caused Cell Clusters complexes cross-neutralize Defense defined Delta determinant determinants determine disease driven by Efficacy escape Fab FIVE greater highest Host host defense identifying Immune escape immune protection Infection initial memory B memory B cell Mitigation Mutation neutralization neutralization potency neutralize neutralized Neutralizing activity Neutralizing antibodies neutralizing antibody omicron Prevalence RBD real-world data Receptor binding domain recognize recognizing Region SARS-CoV-2 SARS-CoV-2 spike glycoprotein SARS-CoV-2 strain sensitivity Specificities specificity spike glycoprotein Spike receptor binding domain Structure structures tested the RBD the SARS-CoV-2 Vaccine vaccine efficacy variant variants variants of concern Viral viral escape viral invasion Wuhan strain [DOI] 10.1126/sciimmunol.abo3425 PMC 바로가기 [Article Type] Article
Targeting SARS-CoV-2 endoribonuclease: a structure-based virtual screening supported by in vitro analysisSARS-CoV-2 엔도리보뉴클레아제 표적화: 체외 분석으로 지원되는 구조 기반 가상 스크리닝Article Published on 2022-08-032022-09-11 Journal: Scientific Reports [Category] SARS, 신약개발, 치료기술, 치료제, [키워드] Analysis approach approach Bank binding affinity binding energy cell line Compound compounds Concentration COVID-19 database deep learning Defense Diversity docking drug Drug Bank drug candidate endoribonuclease evade FIVE followed by Hierarchical Host host defense in vitro in vivo inhibitory concentration Interaction interfere life cycle molecular non-structural protein non-structural proteins Nsp15 Precision predict protocol responsible SARS-CoV-2 screened selectivity index shown supported targeting the binding affinity therapeutic effect Viral RNA Virtual screening virus was used were used [DOI] 10.1038/s41598-022-17573-6 PMC 바로가기 [Article Type] Article
Genome-wide bidirectional CRISPR screens identify mucins as host factors modulating SARS-CoV-2 infection게놈 전체에 걸친 양방향 CRISPR 스크린은 뮤신을 SARS-CoV-2 감염을 조절하는 숙주 인자로 식별합니다Article Published on 2022-08-012022-09-11 Journal: Nature Genetics [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 진단, 치료기술, 치료법, 치료제, [키워드] ACE2 Activation acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus airway Antiviral bidirectional cause clathrin conducted coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 CRISPR CRISPR screen Critical Defense defense mechanism Epigenetic epithelial cell epithelial cells expression Factor family functional highlight Highlights Host host defense human lung human lung epithelial cells identify in vitro infected individuals Infection inflammatory signaling inhibit mechanism mild respiratory modulating molecular weight mucin mucins murine models Pathways progression provide Regulation respiratory respiratory distress Respiratory illness respiratory viruses SARS-CoV-2 SARS-CoV-2 entry factors SARS-COV-2 infection SARS-CoV-2-host interaction SARS-CoV-2-host interactions severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 starting point Symptom syndrome the SARS-CoV-2 TMPRSS2 transcriptional Transport Viral viral infection [DOI] 10.1038/s41588-022-01131-x PMC 바로가기 [Article Type] Article
SARS-CoV-2 virus NSP14 Impairs NRF2/HMOX1 activation by targeting Sirtuin 1SARS-CoV-2 바이러스 NSP14는 Sirtuin 1을 표적으로 하여 NRF2/HMOX1 활성화를 손상시킵니다Article Published on 2022-08-012022-09-11 Journal: Cellular and Molecular Immunology [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료제, [키워드] activate Activation acute respiratory distress acute respiratory distress syndrome antioxidant defense system antiviral activity ARDS Biliverdin catalytic domain cell type COVID-19 pandemic Cytokine storms death Defense Evidence Factor Genetic HMOX1 Host host defense inhibit interact mechanism metabolite MOST Nrf2 nsp14 oxidative stress pathway producing regulated respiratory distress Respiratory failure Respiratory virus infections SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication SARS-CoV-2 virus significantly SIRT1 SIRT1. sirtuin suppressed syndrome Viral protein [DOI] 10.1038/s41423-022-00887-w PMC 바로가기 [Article Type] Article
SARS-CoV-2 nucleocapsid protein triggers hyperinflammation via protein-protein interaction-mediated intracellular Cl – accumulation in respiratory epitheliumSARS-CoV-2 뉴클레오캡시드 단백질은 단백질-단백질 상호작용 매개 세포내 Cl-호흡 상피에서의 축적을 통해 과염증을 유발합니다Article Published on 2022-07-272022-09-11 Journal: Signal Transduction and Targeted Therapy [Category] COVID19(2023년), SARS, 신약개발, 치료법, [키워드] abrogated Airway inflammation CAMP cell lines cells CFTR Concentration COVID-19 cystic fibrosis Cytokine storms Defense demonstrated depleting downregulated elicit epithelial epithelial cell epithelial cells expression fibrosis glucocorticoid Host host defense human airway epithelial hyperinflammation immune response immune responses Inflammatory response Inflammatory responses inhibition inhibitor Intracellular knockout microRNA modulating murine model murine models N protein pathogen phosphodiesterase Phosphorylation promoted Protein pulmonary inflammation raised reducing regulated respiratory epithelium resulting robust Rolipram SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 nucleocapsid second messenger selective serum SGK1 signaling pathway Smad3 structural protein suggested sustained targeting therapeutic strategy transmembrane Trigger upregulation [DOI] 10.1038/s41392-022-01048-1 PMC 바로가기 [Article Type] Article
Immature granulocytes: Innovative biomarker for SARS‑CoV‑2 infection미성숙 과립구: SARS‑CoV‑2 감염에 대한 혁신적인 바이오마커Article Published on 2022-07-012022-09-11 Journal: Molecular medicine reports [Category] COVID19(2023년), MERS, SARS, 바이오마커, 변종, 치료기술, [키워드] acute pancreatitis acute respiratory syndrome addition age Alpha Alpha variant Analysis antiviral immune response Bacterial bacterial and fungal infections Biomarker Biomarkers Bone marrow Cardiopulmonary cardiopulmonary bypass clinical conditions Comorbidities complications confounders coronavirus coronavirus disease Coronavirus disease 2019 COVID‐19 critical cases Defense disease severity duration of hospitalization evaluate evaluated fungal infections granulocyte Granulocytes greater Host host defense immature immature granulocytes in viral include Increased independent Infection infections infectious complication Infectious complications intubation involved Logistic regression analysis Male sex Mortality multivariate logistic regression neutrophil Neutrophils neutrophils. Numerous outcomes Pancreatitis Patient patients hospitalized Peripheral blood precursor precursors presence of comorbidity present prognostic biomarker reported Research respiratory severe acute respiratory syndrome Coronavirus severe and critical cases severity significantly syndrome systemic inflammatory response systemic inflammatory response syndrome variant Viral viral infections was measured [DOI] 10.3892/mmr.2022.12733 PMC 바로가기 [Article Type] Article
The Deubiquitinase USP29 Promotes SARS-CoV-2 Virulence by Preventing Proteasome Degradation of ORF9bDeubiquitinase USP29는 ORF9b의 프로테아좀 분해를 방지하여 SARS-CoV-2 독성을 촉진합니다Article Published on 2022-06-282022-09-11 Journal: mBio [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Alpha Antiviral biological processes canonical carboxyl caused coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Defense Degradation deubiquitinase deubiquitination. develop E3 ubiquitin ligase E3 ubiquitin ligases effort eGFP enhancement Evidence Health healthy help Host host defense hosts IFN IFN-I IKKɑ Immunity inhibit inhibiting innate immune response Intensive interact Interaction IκB mechanisms Modification mRNA level NF-κB NF-κB activation Orf9b Particles pathogen pathogenicity pathway Prevent Preventing proliferation proteasomal proteasome Protein regulate Regulation Replication replication-competent SARS-CoV-2 restrict resulting SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 patient SARS-CoV-2 patients SARS-CoV-2 protein SARS-CoV-2 proteins SARS-CoV-2 virus severe acute respiratory syndrome Coronavirus Signaling subsequent Transcription Type I IFN type I interferon ubiquitin USP29 viral infections virulence [DOI] 10.1128/mbio.01300-22 PMC 바로가기 [Article Type] Article
Emerging Role of ZBP1 in Z-RNA Sensing, Influenza Virus-Induced Cell Death, and Pulmonary InflammationZ-RNA 감지, 인플루엔자 바이러스 유발 세포 사멸 및 폐 염증에서 ZBP1의 새로운 역할Review Published on 2022-06-282022-09-11 Journal: mBio [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antiviral Apoptosis Cell cell death coronavirus Critical cytopathic death Defense epithelial epithelial cell functional highly pathogenic Host host cell host defense human disease IAV immune sensing immunopathology in vivo Infection Inflammasome Inflammation Inflammatory response Inflammatory responses Influenza influenza A influenza A virus influenza infections influenza viruses Innate Innate immunity innate immunity. Lung infection mechanism necroptosis nucleic acid outbreak Pandemics pathogenic pathogenicity proinflammatory Proinflammatory response promote pulmonary pyroptosis Respiratory illness Respiratory tract infections responses RIPK3 RNA RNA virus role SARS-CoV-2 Signaling triggering understanding viral infections viral strain virus virus Z-RNA ZBP1 zoonotic transmission [DOI] 10.1128/mbio.00401-22 PMC 바로가기 [Article Type] Review
Pseudomonas aeruginosa: pathogenesis, virulence factors, antibiotic resistance, interaction with host, technology advances and emerging therapeutics녹농균(Pseudomonas aeruginosa): 병인, 독성 인자, 항생제 내성, 숙주와의 상호 작용, 기술 발전 및 새로운 치료법Review Published on 2022-06-252022-09-11 Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, MERS, 유전자 메커니즘, [키워드] addition Antibiotic resistance Antibiotics antimicrobial autophagy Bacterial Bacterial pathogenesis bioinformatics burn wounds Cancer caused Cell signaling cGAS chronic obstructive clinically COPD COVID-19 CRISPR CRISPR-Ca cystic fibrosis Defense develop disorder drug drug resistance Drug screening effective effort Factor Factors fibrosis gram Host host defense host immune responses host-pathogen interaction immune immune responses immunodeficiency IMPROVE infect Infection infections Inflammasome Interaction intractable invasive LPS mammalian cell mechanism metabolomics molecular Non-coding RNAs opportunistic pathogen outer membrane P. aeruginosa pathogen Pathogenesis Pathways Patient platform Pseudomona Pseudomonas aeruginosa rapid progress Regulation Research scRNA-seq secretion Severe infection signaling pathways Strains therapy traits treat use of antibiotics Ventilation Vesicle virulence widespread [DOI] 10.1038/s41392-022-01056-1 PMC 바로가기 [Article Type] Review